Imbalance, compensation, and rigidity in brain functional connectivity and microstates among older adults with cognitive impairment
Older adults with mild cognitive impairment demonstrated increased abnormal and redundant brain functional connectivity, inefficiency in microstate C, and compensatory mechanisms in low-frequency connectivity in brain functions as well as microstates A, B, and D. Older adults with moderate to severe cognitive impairment displayed sustained compensatory mechanisms in brain functional connectivity and microstates, characterized by dominant abnormal and redundant connections, along with pathological hypersynchrony in microstates B and D, which persisted until rigidity set in.
Authors
- Shufan Li (ORCID: https://orcid.org/0000-0002-6366-7334)
- Xing Wang (ORCID: https://orcid.org/0000-0002-3230-3482)
- Cong Liu (ORCID: https://orcid.org/0000-0001-6387-0482)
- Wei Chen (ORCID: https://orcid.org/0000-0003-4610-8490)
- Qing Liu (ORCID: https://orcid.org/0000-0003-2028-973X)
- Xin Xin (ORCID: https://orcid.org/0000-0003-4899-9127)
- Xinlong Ma (ORCID: https://orcid.org/0009-0008-2649-6346)
- Fengfei Ding (ORCID: https://orcid.org/0000-0001-5589-3668)
- Zhaohui Guo
- Shuqi Jia (ORCID: https://orcid.org/0000-0002-7143-4223)
Institutions
- Shanghai University of Sport (CN)
- Shenyang Normal University (CN)
Publication Details
- Journal
- Journal of NeuroEngineering and Rehabilitation
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12984-025-01803-9
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Office for Philosophy and Social Sciences