Tissue- and Cell-Type-Specific Genetic Regulation of CTBP1 in Breast Cancer: Integrative Analyses with Exploratory Single-Cell and Imaging Data
Our results prioritise CTBP1 as a context-dependent, tissue- and cell-type-specific candidate in breast cancer. The observational and exploratory components warrant validation in larger cohorts and functional assays. To our knowledge, this is the first integrative study combining GWAS, single-cell eQTL and MRI radiomics to prioritize CTBP1 in breast cancer.
Authors
- Xiaowen Huang (ORCID: https://orcid.org/0000-0001-5179-0370)
- Minping Hong
- Zhenyi Ma (ORCID: https://orcid.org/0000-0001-6962-2711)
- Qin Xu (ORCID: https://orcid.org/0009-0004-5916-9828)
- Keng Ling (ORCID: https://orcid.org/0000-0003-0081-5069)
Institutions
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Breast Cancer Targets and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/bctt.s560038
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang Traditional Chinese Medicine Administration
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province