Integrating bioinformatics, molecular dynamics simulation and experimental verification to screen diagnostic biomarkers for polyamine metabolism-related osteoarthritis and predict potential drugs
This study initially identified four genes closely associated with polyamine metabolism-related genes: PLOD1, TSPO, SPP1, and COL6A1. These genes demonstrated potential value in the early diagnosis and precise intervention of OA. Triptolide was also found to have therapeutic potential for treating OA. These findings lay the groundwork for developing OA biomarkers and innovative therapeutic strategies.
Authors
- JunShuai Xue (ORCID: https://orcid.org/0000-0002-2481-9438)
- Chang-Jiao Ji
- Zumin Shi (ORCID: https://orcid.org/0000-0002-3099-3299)
- Wei Wang (ORCID: https://orcid.org/0000-0003-4844-5095)
- Jianxin Zhang (ORCID: https://orcid.org/0000-0002-1176-3703)
- Tao Wei
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s13018-025-06544-y
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00