Estimating the impact of patient-level risk factors and time-varying hospital unit on healthcare-associated <i>Clostridioides difficile</i> infection using cross-classified multilevel models
Using multilevel methods accounting for patient movement, we found that while antibiotic use is the most important risk factor in patients that developed <i>C. difficile</i> infection, environmental risk factors are additionally important and should be considered in research involving hospitalized patients and healthcare-associated infections.
Authors
- Neal D. Goldstein (ORCID: https://orcid.org/0000-0002-9597-5251)
- Stephen C. Eppes
- Jessica L. Webster (ORCID: https://orcid.org/0000-0002-0154-0506)
- Brisa Ney Sánchez (ORCID: https://orcid.org/0000-0002-4824-7200)
- Claudine Jurkovitz (ORCID: https://orcid.org/0000-0002-8957-0100)
Institutions
- Christiana Care Health System (US)
- Institute for Community Health (US)
- Drexel University (US)
Publication Details
- Journal
- Infection Control and Hospital Epidemiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1017/ice.2025.10356
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00