Genome-wide association study of lung function decline using elastic-net regression: a prospective analysis in Korean cohort
Our study identified novel SNPs associated with FEV<sub>1</sub> decline and developed a GRS that could help predict individuals at higher risk of rapid FEV<sub>1</sub> decline. The influence of genetic factors on the annual rate of decline in FEV<sub>1</sub> may vary depending on phenotypic characteristics.
Authors
- Deog Kyeom Kim (ORCID: https://orcid.org/0000-0001-9379-8098)
- Sohee Oh (ORCID: https://orcid.org/0000-0002-3010-448X)
- Jung‐Kyu Lee (ORCID: https://orcid.org/0000-0001-5060-7255)
- Eun Young Heo (ORCID: https://orcid.org/0000-0003-3803-4903)
- Hyun Woo Lee (ORCID: https://orcid.org/0000-0002-6879-9686)
- Eunhye Bae (ORCID: https://orcid.org/0000-0003-1362-7681)
Institutions
- Seoul National University (KR)
- Seoul Metropolitan Government (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Sungae Hospital (KR)
Publication Details
- Journal
- Human Genomics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s40246-025-00862-2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00