Associations between negative symptoms and thermal pain perception in bipolar I disorder
This preliminary study points to the relationship among negative symptom severity and the perception of pain in adults with BD. These findings suggest that thermal pain hypoalgesia in patients with BD may serve as a behavioral marker of negative symptoms, particularly in the MAP domain, potentially reflecting disruptions in sensory-affective integration. Further research with larger samples is warranted to clarify underlying neurobehavioral mechanisms.
Authors
- Jaymin Upadhyay (ORCID: https://orcid.org/0000-0002-8682-163X)
- Jon Haitz Legarreta (ORCID: https://orcid.org/0000-0002-9661-1396)
- Joseph Gonzalez–Heydrich (ORCID: https://orcid.org/0000-0002-3073-983X)
- Mariesa Cay
- Yogesh Rathi (ORCID: https://orcid.org/0000-0002-9946-2314)
- Ann K. Shinn (ORCID: https://orcid.org/0000-0002-5311-6280)
- Emma Golden (ORCID: https://orcid.org/0000-0002-3887-8252)
- Raquel van Gool (ORCID: https://orcid.org/0000-0001-6486-2388)
- Hanne van der Heijden
- Lauren J. O’Donnell (ORCID: https://orcid.org/0000-0003-0197-7801)
- Aliza Ray
- Lise Vrolix
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- McLean Hospital (US)
- Maastricht University (NL)
Publication Details
- Journal
- International Journal of Bipolar Disorders
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s40345-025-00403-9
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00