New Insights Into Curcumin Behavior After Its Biosynthesis in Engineered <scp> <i>Escherichia coli</i> </scp> Through Spectroscopic and Spatial Analysis
These experiments demonstrate that curcumin biosynthesis from ferulic acid leads to significant product aggregation within the cells, which could ultimately halt production by inducing cell death. Understanding the localization, transport, and removal of curcumin is crucial in developing more efficient biosynthetic pathways to enhance its production in microbial systems.
Authors
- M. Tuan Trinh (ORCID: https://orcid.org/0000-0001-8393-5669)
- Jesse B. Brown (ORCID: https://orcid.org/0009-0001-9167-5462)
- Yi Rao (ORCID: https://orcid.org/0000-0001-9882-1314)
- Jixun Zhan (ORCID: https://orcid.org/0000-0003-0200-9183)
- T. T. Trinh Phan
- Hayat Ullah (ORCID: https://orcid.org/0009-0003-7514-5722)
- Hui Wang (ORCID: https://orcid.org/0000-0003-1039-7833)
- Hassan Sher (ORCID: https://orcid.org/0000-0002-6533-455X)
Institutions
- Utah State University (US)
Publication Details
- Journal
- Phytochemical Analysis
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/pca.70041
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00