Immunogenicity of a Lipopolysaccharide Brucella melitensis Vaccine in Goats: An Exploratory Study
Our data suggests that LPS + ISA 61 VG induces a robust humoral response but negligible cellular responses. Our data also suggest that LPS + ISA 61 VG or LPS alone would not be efficacious for use as a vaccine in goats, but the LPS + ISA 61 VG inoculum may be beneficial as a booster. Additional trials would be necessary to evaluate the vaccine's efficacy as a booster inoculation for small ruminants.
Authors
- Joshua B. Daniels
- Μ. D. Salman (ORCID: https://orcid.org/0000-0001-5982-6331)
- Alnakhli Naseer
- Brian J. McCluskey
- Steven C. Olsen (ORCID: https://orcid.org/0000-0002-4136-3831)
Institutions
- Agricultural Research Service (US)
- National Animal Disease Center (US)
- Colorado State University (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-11-29
- DOI
- https://doi.org/10.3390/vaccines13121209
- Primary Topic
- Brucella: diagnosis, epidemiology, treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture
- Colorado State University