Patient Plasma‐Induced Neutrophil Dysfunction Is Associated With Infection Risk and Mortality in Patients With Acute Decompensation of Cirrhosis
Plasma from patients with AD induces a 'primed but exhausted' neutrophil phenotype, characterised by a paradoxical failure to respond to stimuli. This dysfunction was associated with an increased risk of infection and mortality, particularly in AD-NoACLF patients. PIND offers a promising strategy to improve risk stratification in this high-risk population.
Authors
- Jane Macnaughtan (ORCID: https://orcid.org/0000-0003-1211-9298)
- Su Lin (ORCID: https://orcid.org/0000-0001-7517-9859)
- Rohit Sawhney (ORCID: https://orcid.org/0000-0002-8131-2182)
- Nathan Davies (ORCID: https://orcid.org/0000-0003-1625-9204)
- Rajiv Jalan (ORCID: https://orcid.org/0000-0002-7747-4015)
- Supachaya Sriphoosanaphan (ORCID: https://orcid.org/0000-0003-1711-7099)
- Emmanuel Wey (ORCID: https://orcid.org/0000-0003-2985-9524)
- Haw Lu
- Rocío Gallego‐Durán (ORCID: https://orcid.org/0000-0002-9452-1661)
- Qianwen Zhao (ORCID: https://orcid.org/0009-0003-0361-1181)
- Rajeshwar P. Mookerjee (ORCID: https://orcid.org/0000-0002-6275-9384)
Institutions
- Chulalongkorn University (TH)
- Sichuan University (CN)
- King Chulalongkorn Memorial Hospital (TH)
- West China Hospital of Sichuan University (CN)
- Eastern Health (AU)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Institute for Liver Health (US)
- University College London (GB)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1111/apt.70480
- Citations
- 2
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 2.64