Post Thrombolytic Angiographic Profile and TIMI Flow in Patients with ST-Elevation Myocardial Infarction Receiving Thrombolytic Therapy

Background: The term "myocardial infarction" (MI) is frequently used to describe the mortality of cardiomyocytes that results from a prolonged and significant ischemia that is caused by an imbalance in oxygen supply and demand. The objective of this study was to assess the angiographic characteristics and angiographic efficacy of thrombolysis in relationship to the flow of thrombolysis in myocardial infarction patients ("TIMI") who underwent angiography subsequent to ST-segment elevation myocardial infarction (STEMI) thrombolysis. Furthermore, most frequently associated risk factors with unsuccessful thrombolysis were identified. Methods: This dual center and prospective observational study included 130 STEMI patients in the CCU unit, both Benha University Hospital and National Heart Institute. Patients were divided into two groups angiographic TIMI flow post-thrombolytic therapy Group I (n= 44): patients with TIMI flow ≤ 2 and group II (n=86): patients with TIMI flow 3. Results: In the univariate analysis, diabetes mellitus presence, hypertension, hyperlipidemia, a history of coronary artery disease, a longer duration from the onset of symptoms to the thrombolytic, a lower systolic blood pressure, a lower diastolic blood pressure, a higher random blood glucose (RBG), an increased alanine aminotransferase, a lower left ventricular ejection fraction, an increased number of vessels affected, the presence of ostial segment affection, and a high thrombus Burden Grade were all associated with an increased risk of TIMI 2 flow or less. Conclusion: Incidence of TIMI flow < 3 in STEMI patients received thrombolytic therapy was 33.8%.