Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma (PRP) for the Treatment of Female Sexual Dysfunction

Background: Female sexual dysfunction (FSD) affects up to 78% of women and significantly impairs quality of life. This investigation was designed to assess the therapeutic impact of autologous PRP injections targeted to the anterior vaginal wall at the G-spot region in women presenting with female sexual dysfunction (FSD). Patients and Methods: A prospective interventional study was conducted on 33 married women with confirmed FSD, defined by a Female Sexual Function Index (FSFI) score ≤26.5 and orgasm domain score ≤3.75. PRP was processed around the clitoral region into the paraurethral segment of the vaginal wall at 3-week intervals. Clinical outcomes were evaluated through FSFI and the Female Sexual Distress Scale–Revised (FSDS-R) at baseline, 3, 6, and 9 weeks, and at 6-month follow-up. Results: At baseline, mean FSFI was <26, with subdomain scores as follows: desire 3.19 ± 1.15, arousal 2.35 ± 1.47, lubrication 2.15 ± 1.27, orgasm 2.14 ± 1.30, satisfaction 1.88 ± 1.62, and pain 1.69 ± 1.38. Pre-treatment FSDS-R averaged 20.11 ± 11.1. FSFI demonstrated significant improvement at 3 weeks (17.53 ± 2.68) and progressively increased, peaking at 28.68 ± 4.10 by 6 months (p<0.001). Parallel reduction in sexual distress was noted, with FSDS-R declining to 12.32 ± 3.1 at 6 months (p<0.001). Enhancements were significant across all FSFI domainsConclusion: Localized PRP injection constitutes a promising and safe intervention for FSD, offering substantial improvements in sexual desire, arousal, lubrication, orgasm, and satisfaction, alongside reductions in distress levels. Further large-scale, multicenter studies are required to corroborate these preliminary results.