PPARγ as a predictive biomarker for antidepressant response in major depressive disorder: Insights from TNIP1 transcriptional regulation
This study highlights the differential expression of PPAR-γ, FOS, and JUN in MDD patients, underscoring their potential roles in immune regulation. The association between lower pre-treatment PPAR-γ expression and improved treatment outcomes suggests its utility as a biomarker for predicting therapeutic response.
Authors
- Daw‐Yang Hwang (ORCID: https://orcid.org/0000-0002-5139-3612)
- Yi-Yung Hung
- Yu‐Wei Lin (ORCID: https://orcid.org/0000-0001-7352-0750)
Institutions
- National Health Research Institutes (TW)
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Kaohsiung Municipal Hsiao-Kang Hospital (TW)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.bbih.2025.101151
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00