Registration and reporting of clinical trials affiliated with California universities and with primary completion date from 2014 to 2017

Almost one fifth of clinical trials with primary completion dates from 2014 to 2017 with investigators, sponsors or responsible parties affiliated with seven California biomedical research universities lacked any results reporting 5 years after their primary completion, and only 58% reported results within 2 years. Even though a large majority of these trials were completed before US legal mandates for reporting, there was an ethical requirement that the burden to research participants should be commensurate with the scientific value of the research. Research has no public scientific value if its results are not reported.

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Publication Details

Journal
Trials
Published
2025-12-01
DOI
https://doi.org/10.1186/s13063-025-09270-2
Primary Topic
Ethics in Clinical Research
Type
article
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article

Registration and reporting of clinical trials affiliated with California universities and with primary completion date from 2014 to 2017

Delwen Franzen, Stefanie Gestrich, Vladislav Nachev, Emmanuel A. Zavalis et al.
Trials
Ethics in Clinical Research
article

Registration and reporting of clinical trials affiliated with California universities and with primary completion date from 2014 to 2017

Delwen Franzen, Stefanie Gestrich, Vladislav Nachev, Emmanuel A. Zavalis, Mario Malički, Steven N. Goodman, Susanne Wieschowski, Samruddhi Yerunkar, Daniel Strech, Benjamin Gregory Carlisle, Maia Salholz‐Hillel, Nicole Hildebrand
article en

Abstract

Almost one fifth of clinical trials with primary completion dates from 2014 to 2017 with investigators, sponsors or responsible parties affiliated with seven California biomedical research universities lacked any results reporting 5 years after their primary completion, and only 58% reported results within 2 years. Even though a large majority of these trials were completed before US legal mandates for reporting, there was an ethical requirement that the burden to research participants should be commensurate with the scientific value of the research. Research has no public scientific value if its results are not reported.

TrialsVol. 27(1)
Ethics and Public Policy Center (US), Karolinska Institutet (SE), University of Maribor (SI), Protein Metrics (United States) (US), Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE), Innovative Research (United States) (US), Meio University (JP), Stanford University (US)
Openalex Percentile: Top 52%
Ethics in Clinical Research
DOIOpen Access PDFOpenAlex
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Registration and reporting of clinical trials affiliated with California universities and with primary completion date from 2014 to 2017 — Delwen Franzen, Stefanie Gestrich, et al. · Trials (2025) | TGRS Research Map | TGRS