The metabolic crossroads: glycolysis in cancer and neurodegeneration
Our findings identify glycolysis as a shared but oppositely regulated pathway linking cancer and neurodegeneration. ACAA2 may serve as a molecular mediator of this metabolic divergence, offering new insights into disease crosstalk and potential therapeutic targets.
Authors
- Shaopeng Zeng
- Ying Yang (ORCID: https://orcid.org/0000-0002-2032-9183)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-7222-8317)
- Huan Liu (ORCID: https://orcid.org/0000-0002-9947-6687)
- Jun Chen (ORCID: https://orcid.org/0009-0004-5297-6790)
- Shilong Han
Institutions
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s12883-025-04533-6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00