Global Innovations in Sustainable Pharmaceutical Packaging in the Last 25 Years: A Scoping Review

Pharmaceutical packaging is integral to the efficacy, safety, quality and regulatory compliance of medicinal products. However, traditional pharmaceutical packaging can cause harmful environmental effects due to a lack of eco-design methods, excessive use of synthetic materials, and a lack of effective recycling techniques. In response, a range of innovations in sustainable pharmaceutical packaging have emerged to mitigate these environmental effects. This scoping review aims to identify and map global innovations in sustainable pharmaceutical packaging developed within the last 25 years, examine implementation challenges, identify gaps in the literature, and suggest a framework to guide the pharmaceutical industry in adopting these eco-innovations. Following the PRISMA-ScR guidelines, this review analysed 100 studies from grey and academic literature published between the years 2000 and 2025. Data extraction and thematic analysis was performed and revealed four main areas of innovation: biodegradable materials, design, smart technology, and waste management. Key barriers to their adoption include regulatory, safety, and economic challenges. One gap identified in the literaturewas the lack of a framework to aid the implementation of innovations in sustainable pharmaceutical packaging. Therefore, this review also proposes a responsible packaging innovation framework.