Glial activation and increase in cerebral pro-inflammatory cytokine expression in a female animal post-COVID model
This study provides evidence on brain neuro-inflammation, highlighting glial activation and IL-18 overexpression after an acute SARS-CoV-2 infection. These findings improve current understanding of post-COVID neuroinflammation and could aid in the design of treatment strategies for persistent neurological sequelae, such as cognitive impairment and mental confusion.
Authors
- Carlos Goicoechea
- César Fernández‐de‐las‐Peñas (ORCID: https://orcid.org/0000-0003-3772-9690)
- Lars Arendt‐Nielsen (ORCID: https://orcid.org/0000-0003-0892-1579)
- Visitación López‐Miranda (ORCID: https://orcid.org/0000-0003-1378-0387)
- Esperanza Herradón (ORCID: https://orcid.org/0000-0001-7210-6283)
- Eva M. Sánchez‐Robles (ORCID: https://orcid.org/0000-0002-2740-2750)
- S. Prados
Institutions
- Steno Diabetes Centers (DK)
- Universidad Rey Juan Carlos (ES)
- Aalborg University Hospital (DK)
- Mech-Sense (DK)
- Instituto de Química Médica (ES)
- Aalborg University (DK)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.bbih.2025.101148
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria