Effect of ibuprofen on the pharmacokinetics of intravenous flucloxacillin in healthy adults
Orally administered ibuprofen had no measurable effect on plasma flucloxacillin PK in healthy adults. Given the lack of drug-drug interaction, there is no benefit to prescribing ibuprofen alongside flucloxacillin to increase flucloxacillin exposure.
Authors
- Roberts Ja
- Alison Boast (ORCID: https://orcid.org/0000-0002-9093-3992)
- Stephen B. Duffull (ORCID: https://orcid.org/0000-0002-6545-9408)
- Amy Legg (ORCID: https://orcid.org/0000-0001-8228-1536)
- Amanda Gwee (ORCID: https://orcid.org/0000-0003-4016-8986)
- John J. McCarthy (ORCID: https://orcid.org/0000-0002-8495-9096)
- Tong Syc
Institutions
- Royal Children's Hospital (AU)
- The University of Queensland (AU)
- Charles Darwin University (AU)
- Peter Doherty Institute (AU)
- Certara (United States) (US)
- Royal Darwin Hospital (AU)
- Integra LifeSciences (United States) (US)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107684
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00