miR-23a-5p Alleviates Gouty Inflammation by Targeting Interleukin-17A and Inhibiting NLR Family Pyrin Domain Containing 3 Inflammasome Activation

This study demonstrated that miR-23a-5p alleviates MSUinduced gouty inflammation by directly targeting IL-17A. Through this regulation, miR-23a-5p suppresses NLRP3 inflammasome activation, highlighting its potential as a therapeutic target for gout. Cite this article as: Yuan X, Lin C, Zhang Y, He H, Li L. MiR-23a-5p alleviates gouty inflammation by targeting interleukin-17A and inhibiting NLR family pyrin domain containing 3 inflammasome activation. Arch Rheumatol. 2025;40(4):443-451.