Lipoprotein(a) testing trends in young ischemic stroke patients from 2015-2024: An analysis of 188,000 individuals
Lp(a) testing among young ischemic stroke patients has increased significantly over the past decade, likely reflecting growing clinical recognition of its causal role in atherosclerotic disease. The rise parallels key updates in lipid management and stroke prevention guidelines, including the 2019 European Society of Cardiology and 2024 National Lipid Association recommendations advocating at least once-in-a-lifetime Lp(a) measurement. Increasing assay availability and heightened awareness of the causal relationship of Lp(a) with atherosclerotic disease may also have contributed to the observed upward trend. Despite this, only about one in twenty young ischemic stroke patients had ever been tested, underscoring a substantial implementation gap between evidence and clinical practice.
Authors
- Ehtisham Mahmud (ORCID: https://orcid.org/0000-0003-2493-8661)
- Brett C. Meyer (ORCID: https://orcid.org/0000-0002-2877-1187)
- Mattheus Ramsis (ORCID: https://orcid.org/0000-0002-0666-8461)
- Michael J. Wilkinson (ORCID: https://orcid.org/0000-0002-3800-7369)
- Raphael Cuomo (ORCID: https://orcid.org/0000-0002-8179-0619)
- Félix López de Felipe (ORCID: https://orcid.org/0000-0001-5661-8115)
- Pam R. Taub (ORCID: https://orcid.org/0000-0002-0684-0655)
- Harpreet Singh Bhatia (ORCID: https://orcid.org/0000-0002-3964-2989)
- Mustafa Naguib
Institutions
- UC San Diego Health System (US)
- University of California San Diego (US)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108513
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- University of California, San Diego