Front Cover: Optimizing the Cell Number and Size for Tumor Spheroid Modeling Using Amyloid Hydrogel (ChemBioChem 23/2025)

The cover demonstrates the tumor spheroid formation by cancer cells when mixed with amyloid based KLMEI peptide sequence (sequence is in inset) hydrogels. The background shows the SEM image of the amyloid hydrogel fibrils mimicking the extra cellular matrix, which promotes growth and proliferation of MCF7 cells into 3D tumor spheroid. The illustration of a 24-well plate containing the drop cast 3D spheroids with a magnified confocal image of an actual MCF 7 spheroid exhibits live cells at the outer regions with a central necrotic core, reminiscent of in vivo tumors. More details can be found in the Research Article by Komal Patel, Samir K. Maji, and co-workers (DOI: 10.1002/cbic.202400595).