A case of adrenal endothelial cyst (vascular type) with positive 123I-MIBG uptake
<sup>123</sup>I-metaiodobenzylguanidine (MIBG) scintigraphy is highly accurate for diagnosing pheochromocytoma and paraganglioma (PPGL), and positive uptake in non-PPGL adrenal lesions is rare. We report a 56-year-old woman with an adrenal endothelial cyst (vascular type) showing localized <sup>123</sup>I-MIBG uptake, initially suspected to be pheochromocytoma. After mild growth during observation, robot-assisted adrenalectomy was performed. Histopathology confirmed an endothelial cyst positive for CD31 and D2-40. Among 601 adrenalectomies, eight adrenal endothelial cysts (1.3 %) were identified, three showing MIBG uptake. Adrenal endothelial cysts may rarely show MIBG uptake, complicating preoperative differentiation from PPGL.
Authors
- Hideki Katagiri (ORCID: https://orcid.org/0000-0003-1093-3704)
- Yoshikiyo Ono (ORCID: https://orcid.org/0000-0003-1873-7388)
- Hiromichi Katayama (ORCID: https://orcid.org/0000-0001-8339-5164)
- Tomonori Sato (ORCID: https://orcid.org/0000-0001-5659-6809)
- Naoki Kawamorita (ORCID: https://orcid.org/0000-0001-6175-3063)
- Yohei Satake (ORCID: https://orcid.org/0000-0003-3961-1004)
- Yuto Yamazaki (ORCID: https://orcid.org/0000-0002-9976-2632)
- Rieko Asai (ORCID: https://orcid.org/0000-0002-3826-8083)
- Yuta Tezuka (ORCID: https://orcid.org/0000-0003-1546-6949)
- Takuma Sato (ORCID: https://orcid.org/0000-0002-2213-3117)
- Akihiro Itô (ORCID: https://orcid.org/0000-0002-8698-0032)
- Yoshihide Kawasaki (ORCID: https://orcid.org/0000-0001-6425-3574)
Institutions
- Tohoku University Hospital (JP)
Publication Details
- Journal
- Urology Case Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.eucr.2025.103298
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 0.00