Combining topical and intravenous tranexamic acid in cardiac surgery: does it really matter? – a systematic review and meta-analysis
Combined topical and IV TXA application is associated with reduced total blood loss after cardiac surgery compared to an IV-only approach. However, no significant differences were observed in transfusion rates, blood product utilization, or mortality.
Authors
- Felipe S. Passos
- Túlio Caldonazo (ORCID: https://orcid.org/0000-0001-5697-2659)
- Hristo Kirov (ORCID: https://orcid.org/0000-0001-5886-3472)
- Letizia Consoli (ORCID: https://orcid.org/0000-0001-6954-6114)
- Amrinder Kaur (ORCID: https://orcid.org/0000-0002-1035-7762)
- S.S. Dani
- Torsten Doenst
- Paul Onyeji
- Sonise Momplaisir-Onyeji
Institutions
- Universidade Federal da Bahia (BR)
- Cornell University (US)
- Dominica State College (DM)
- University of Chicago (US)
- Ross University School of Medicine (BB)
- Jena University Hospital (DE)
- Mater Dei Hospital (BR)
- B.J. Medical College (IN)
Publication Details
- Journal
- IJC Heart & Vasculature
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.ijcha.2025.101848
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 0.00