Ag( <scp>i</scp> )-mediated <i>mono</i> -selective C(sp <sup>2</sup> )–H chalcogenation of α-aminotropones and their peptides at room temperature
This report describes an Ag(I)-mediated strategy for the <i>mono</i>-selective chalcogenation of α-aminotropones and their peptides with a range of disulfides and diselenides at ambient temperature. The method efficiently furnishes <i>mono</i>-chalcogenated aminotropone derivatives in moderate to good yields, while demonstrating compatibility with diverse substrates and functional groups, offering synthetic versatility in downstream applications.
Authors
- Nagendra K. Sharma (ORCID: https://orcid.org/0000-0003-0901-0523)
- Malobika Kar (ORCID: https://orcid.org/0000-0002-5859-8821)
Institutions
- National Institute of Science Education and Research (IN)
- Homi Bhabha National Institute (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1039/d5cc05556c
- Citations
- 1
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Institute of Science Education and Research
- Science and Engineering Research Board