Transmitter and ion channel profiles of saccadic omnipause neurons and cholinergic non-omnipause neurons in human nucleus raphe interpositus
OPNs and cholinergic non-OPNs are located intermingled within the traditionally identified RIP, however they expressed distinct histochemical signatures from OPNs. Although the functional significance of the cholinergic non-OPN population in human brainstem is unclear, these findings suggest important distinguishing features that could be missed in histopathological examinations of post-mortem cases with saccadic disorders.
Authors
- Anja K. E. Horn (ORCID: https://orcid.org/0000-0001-7797-1516)
- Ümit S. Mayadali
- M. Pandolfi John
- Aasef G. Shaikh (ORCID: https://orcid.org/0000-0002-4772-2823)
- Christoph Schmitz (ORCID: https://orcid.org/0000-0002-4065-1241)
- Michael Abspacher
Institutions
- University Hospitals of Cleveland (US)
- LMU Klinikum (DE)
- Case Western Reserve University (US)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Neuroanatomy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fnana.2025.1670220
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft