Integrative multi-omics analysis identifies a PTM-related immune signature and IRF9 as a driver in ccRCC
PTMRS is a PTM-informed immune signature that reflects an immunosuppressive tumor microenvironment, improves prognostic stratification, and indicates ICI benefit in ccRCC. Experimental data pinpoint IRF9 as a functional driver and potential therapeutic target within this PTM-immunity axis.
Authors
- Simeng Hu (ORCID: https://orcid.org/0000-0002-2446-3929)
- Zixiang Li (ORCID: https://orcid.org/0000-0002-8570-8862)
- Xun Li (ORCID: https://orcid.org/0000-0003-3963-3561)
- Junqi Wang (ORCID: https://orcid.org/0000-0001-5192-7234)
- Shan Jiang (ORCID: https://orcid.org/0000-0002-7130-0399)
Institutions
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1707375
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00