Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization and in vivo evidence

This study provides evidence for a potential causal link between elevated vitamin E levels and increased susceptibility to viral infection, as well as between bacterial infection and reduced 25(OH)D levels. Furthermore, our <i>in vivo</i> data demonstrated that sepsis (induced by intraperitoneal bacterial infection) led to a significant decrease in serum 25(OH)D levels.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-12-01
DOI
https://doi.org/10.3389/fimmu.2025.1674678
Primary Topic
Antioxidant Activity and Oxidative Stress
Type
article
Field-Weighted Citation Impact
0.00

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article

Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization and in vivo evidence

Weizhen Zhang, Yijun Shi, Mingming Jin, A-ling Tang et al.
Frontiers in Immunology
Antioxidant Activity and Oxidative Stress
article

Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization and in vivo evidence

Weizhen Zhang, Yijun Shi, Mingming Jin, A-ling Tang, Wei Chen, Zhimin Gong, Lichao Sun
article en

Abstract

This study provides evidence for a potential causal link between elevated vitamin E levels and increased susceptibility to viral infection, as well as between bacterial infection and reduced 25(OH)D levels. Furthermore, our <i>in vivo</i> data demonstrated that sepsis (induced by intraperitoneal bacterial infection) led to a significant decrease in serum 25(OH)D levels.

Frontiers in ImmunologyVol. 16
China-Japan Friendship Hospital (CN), Shanghai University of Traditional Chinese Medicine (CN), Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN), Shanghai University of Medicine and Health Sciences (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 62%
Antioxidant Activity and Oxidative Stress
DOIOpen Access PDFOpenAlex
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Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization and in vivo evidence — Weizhen Zhang, Yijun Shi, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS