An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure
In AD-OSA, OSA exacerbation is associated with memory impairment and executive dysfunction, P-tau 396 elevation and CDK5 decline in CSF, synaptic disruption, and brain atrophy. Additionally, CDK5 may represent a potential therapeutic target for the individuals with comorbid AD and OSA.
Authors
- Yue Huang (ORCID: https://orcid.org/0000-0001-6051-2241)
- Gaifen Liu (ORCID: https://orcid.org/0000-0002-7038-3444)
- Dongmei Luo
- Zijing Zheng (ORCID: https://orcid.org/0000-0001-7329-2452)
- Mingyue He (ORCID: https://orcid.org/0009-0004-6416-8774)
- Hao Yue
- Zhan Liu (ORCID: https://orcid.org/0000-0001-5214-1284)
- Fan Zhang (ORCID: https://orcid.org/0000-0003-2629-2104)
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-2379-5614)
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-7153-4358)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-4832-6961)
- Weijia Zhang (ORCID: https://orcid.org/0000-0001-8103-5325)
- Jing Li (ORCID: https://orcid.org/0000-0002-1294-4020)
- Jinghui Li (ORCID: https://orcid.org/0000-0002-5095-3921)
- Tenghong Lian
- Yao Meng (ORCID: https://orcid.org/0000-0002-5849-2824)
- Ning Wei (ORCID: https://orcid.org/0000-0002-6409-7433)
- Jing Qi (ORCID: https://orcid.org/0000-0003-1027-6687)
- Huiying Guan
- Peng Guo (ORCID: https://orcid.org/0000-0002-5239-2312)
Institutions
- Capital Medical University (CN)
- UNSW Sydney (AU)
- Beijing Tian Tan Hospital (CN)
- Chinese Institute for Brain Research (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fnagi.2025.1552535
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China