Pan-cancer multi-omics analysis of CCT4 in tumor progression and cancer immunity, with focus on lung adenocarcinoma
CCT4 links enhanced proteostasis with immune evasion in LUAD, acting partly through TRiC complex activity and possibly through independent nuclear functions. These findings refine the understanding of how proteostatic machinery contributes to immune modulation in cancer and highlight CCT4 as a potential molecular node bridging tumor growth and immune suppression.
Authors
- Junjie Wen
- Yonghui Wu (ORCID: https://orcid.org/0000-0001-9521-9344)
- Desheng Zhou
- Zhenpeng Wu (ORCID: https://orcid.org/0009-0006-1095-0431)
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1714837
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00