Differential impacts of hemin and free iron on amoxicillin susceptibility in ex vivo gut microbial communities
This <i>ex vivo</i> pipeline enables reproducible assessment of how metabolic modulators like hemin alter amoxicillin susceptibility, highlighting a link between iron-sequestering genera and antibiotic-protection. Future mechanistic insights may support hemin-based strategies to boost antibiotic efficacy.
Authors
- F. Pagano (ORCID: https://orcid.org/0000-0002-6250-8315)
- Peter Belenky (ORCID: https://orcid.org/0000-0002-1682-945X)
- Jason M. Shapiro (ORCID: https://orcid.org/0000-0002-7211-7430)
- Rahiya Rehman (ORCID: https://orcid.org/0000-0002-5338-4787)
- Devin H. Bemis (ORCID: https://orcid.org/0009-0001-4483-0941)
Institutions
- Brown University (US)
- Hasbro Children's Hospital (US)
- Saint Louis University (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fmicb.2025.1629464
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture
- Brown University
- National Institute of Food and Agriculture
- National Institute of Diabetes and Digestive and Kidney Diseases