Integrating multi-omics, network pharmacology, and experimental validation to unveil the molecular mechanisms of Fructus Xanthii in treating asthma
<i>Fructus Xanthii</i> exerts anti-asthmatic effects by modulating HSP90AB1/IL6/TNF and PI3K-AKT pathways, regulating inflammation, cell cycle, apoptosis, and immune homeostasis, providing empirical support for multi-target traditional Chinese medicine strategies in asthma management.
Authors
- Dong Yin (ORCID: https://orcid.org/0000-0002-1878-4849)
- Yuanda Song (ORCID: https://orcid.org/0000-0002-8565-6724)
- Yilin Fan (ORCID: https://orcid.org/0000-0001-7713-4152)
- Xiaoxiao Li (ORCID: https://orcid.org/0000-0002-9158-9556)
- Fan Zhang (ORCID: https://orcid.org/0000-0002-8576-0273)
- Dong Wang (ORCID: https://orcid.org/0009-0003-3322-6284)
- Yucheng Ming
Institutions
- Qilu University of Technology (CN)
- Shandong Iron and Steel Group (China) (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fphar.2025.1722150
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00