Correlation between oral microbial characteristics and overall bone density of Postmenopausal women based on macrogenomic analysis
This exploratory study utilized metagenomic sequencing to analyze the relationship between oral microbiota and PMO while controlling for key confounders. We identified significant compositional and functional alterations in the oral microbiome associated with bone mineral density status, including specific bacterial species showing marked intergroup differences. A model based on differential microbial features exhibited preliminary discriminative capacity, and functional analysis suggested involvement of inflammatory and metabolic pathways. These findings provide initial evidence linking oral microbiota to PMO.
Authors
- Dali Zheng (ORCID: https://orcid.org/0000-0003-2345-4040)
- Yongjun Tang (ORCID: https://orcid.org/0000-0002-7526-1112)
- Xixi Huang (ORCID: https://orcid.org/0000-0002-6822-8373)
- Chanjuan Ye (ORCID: https://orcid.org/0000-0003-2810-9254)
- Youguang Lu (ORCID: https://orcid.org/0000-0002-1325-3790)
- Min Wu (ORCID: https://orcid.org/0000-0003-4485-975X)
- Lu Zhou (ORCID: https://orcid.org/0000-0002-2688-7135)
- Qian Lin (ORCID: https://orcid.org/0000-0003-3362-8454)
- Zhifeng Lin
- Man Liu (ORCID: https://orcid.org/0009-0001-3980-3703)
Institutions
- Fujian Medical University (CN)
- Shenzhen Polytechnic University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fcimb.2025.1663645
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shenzhen Polytechnic