Improved exposure of curcumin-loaded nanocapsules: drug quantification in LPS-induced Drosophila melanogaster and pharmacokinetics in Wistar rats
Nanoencapsulation significantly enhanced CUR exposure in both invertebrate and mammalian systems. This cross-species analytical strategy supports <i>D. melanogaster</i> as a complementary quantitative platform for early pharmacokinetic screening and reinforces NC-CUR as a promising formulation for future translational development in inflammatory conditions.
Authors
- Camila de Oliveira Pacheco (ORCID: https://orcid.org/0009-0006-1691-3543)
- Eliana Jardim Fernandes (ORCID: https://orcid.org/0000-0002-9451-674X)
- Gustavo Petri Guerra (ORCID: https://orcid.org/0000-0001-6995-5348)
- José Roberto Ferreira (ORCID: https://orcid.org/0000-0001-9657-4698)
- Francine Johansson Azeredo (ORCID: https://orcid.org/0000-0003-3625-0186)
- Flávia Elizabete Guerra Teixeira (ORCID: https://orcid.org/0000-0001-7194-0700)
- Sandra Elisa Haas (ORCID: https://orcid.org/0000-0002-5687-6736)
- Ana Pozzato Funghetto-Ribeiro
Institutions
- Universidade Federal de Santa Maria (BR)
- Flometrics (United States) (US)
- Universidade Federal do Pampa (BR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fphar.2025.1688992
- Citations
- 1
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Universidade Federal do Pampa