Estimation of the inflammatory biomarker IL-6 in blood samples from varicose veins after repeated sirāvyadha (venesection/bloodletting)

In all 5 cases, a reduction in the rate of IL-6 was observed. Remarkably, three patients with initially high values showed a statistically significant reduction (<i>p</i> < 0.05) after sirāvyadha treatment, indicating a reduction in inflammation. Clinical and statistical significance (<i>p</i> < 0.05) were also observed in subjective parameters such as pain, edema, tortuosity, and skin pigmentation. Although itching decreased in patients, it did not reach statistical significance, possibly due to some patients not experiencing itching before the procedure. The study demonstrates that sirāvyadha effectively reduces the inflammatory response and subjective symptoms of varicose veins. Furthermore, the improvement in the quality of life after sirāvyadha was highly significant (<i>p</i> < 0.05). Overall, the study supports sirāvyadha's efficacy in reducing inflammatory biomarker IL-6 and subjective symptoms in varicose veins.