Post-marketing surveillance of upadacitinib: multilevel analysis of venous thromboembolism reporting in global data and rheumatoid arthritis
Upadacitinib-related VTE cases display distinct clinical characteristics. These findings support continued pharmacovigilance and the need for robust real-world studies to clarify absolute and comparative risks, inform regulation, and guide personalised therapeutic strategies in RA.
Authors
- Inês Mariana Lourenço (ORCID: https://orcid.org/0000-0003-0752-0802)
- Marta Isabel Pereira (ORCID: https://orcid.org/0000-0002-9678-3200)
- Alexandre Abreu (ORCID: https://orcid.org/0000-0002-3605-9691)
- Mariana Lobo (ORCID: https://orcid.org/0000-0003-3890-7735)
- Inês Ribeiro‐Vaz (ORCID: https://orcid.org/0000-0002-3442-8158)
- Renato Ferreira‐da‐Silva (ORCID: https://orcid.org/0000-0001-6517-6021)
- Manuela Morato (ORCID: https://orcid.org/0000-0002-9509-0613)
- Tayanny Margarida Menezes Almeida Biase (ORCID: https://orcid.org/0000-0003-2133-2621)
- Lourdes Gouveia
- Mário Forrester (ORCID: https://orcid.org/0000-0003-3966-7841)
- Jorge Polónia (ORCID: https://orcid.org/0000-0002-0133-7217)
- Juliana Pereira-Macedo (ORCID: https://orcid.org/0000-0001-9271-0277)
- Nuno F. Rodrigues (ORCID: https://orcid.org/0000-0003-4884-0984)
- Manuela Pinto (ORCID: https://orcid.org/0009-0008-8759-1486)
- C Rodríguez (ORCID: https://orcid.org/0009-0002-0797-5882)
- Isabel Vieira
- Lurdes Silva (ORCID: https://orcid.org/0009-0000-7221-7856)
- Beatriz Mós
Institutions
- Universidade do Porto (PT)
- Hospital de São João (PT)
- Hospital de Santo António (PT)
- Decision Sciences (United States) (US)
- Rede de Química e Tecnologia (PT)
- Centro Hospitalar de Vila Nova de Gaia (PT)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fmed.2025.1683751
- Citations
- 2
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- European Commission
- European Regional Development Fund