Acetyl-11-keto-beta-boswellic acid ameliorates monosodium iodoacetate-induced osteoarthritis in rats: implications of HMGB1/TLR4/NF-κB and Nrf2/HO-1
Together, AKBA demonstrated a protective function in OA by inhibiting inflammatory signaling through the HMGB1/TLR4/NF-κB pathway, augmenting the cytoprotective Nrf2/HO-1 pathway, and regulating necroptosis signaling cascades.
Authors
- Hagar B. Abo-Zalam (ORCID: https://orcid.org/0000-0002-9295-8739)
- Heba Mohammed Refat M. Selim (ORCID: https://orcid.org/0000-0001-6973-6460)
- Bassam Mohamed Ali (ORCID: https://orcid.org/0009-0006-5972-7935)
- Abdallah M. Gendy (ORCID: https://orcid.org/0000-0001-5032-3594)
- Asmaa Saleh (ORCID: https://orcid.org/0000-0002-6286-319X)
- Ghada M. Ragab (ORCID: https://orcid.org/0000-0002-6343-8507)
- Amira A. El-Gazar (ORCID: https://orcid.org/0000-0002-8372-4682)
- Fatemah A. Alherz (ORCID: https://orcid.org/0000-0002-6877-5158)
- Einas Yousef (ORCID: https://orcid.org/0000-0002-8935-0183)
- Najat O. Hamed
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Alfaisal University (SA)
- Misr University for Science and Technology (EG)
- Riyadh Elm University (SA)
- October 6 University (EG)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fphar.2025.1694803
- Primary Topic
- Pharmacological Effects of Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AlMaarefa University
- Princess Nourah Bint Abdulrahman University
- Alfaisal University