Alterations in gut microbiota and plasma metabolites: a multi-omics study of mild cognitive impairment in Parkinson’s disease
Our multi-omics study revealed distinct gut microbiota and metabolite alterations in PD patients with cognitive impairment, highlighting gut-brain axis dysfunction. Key microbial and metabolic markers demonstrated diagnostic potential, providing new insights into the pathophysiology of PD-related cognitive decline and potential targets for future therapeutic strategies.
Authors
- Guiyun Cui (ORCID: https://orcid.org/0009-0006-4782-0147)
- Kun Zan (ORCID: https://orcid.org/0009-0007-7985-4912)
- Xiaojie Wang (ORCID: https://orcid.org/0000-0003-4817-5830)
- Lu Yu (ORCID: https://orcid.org/0000-0002-2110-9019)
- Yuning Liu (ORCID: https://orcid.org/0000-0002-0513-4011)
- Liying Yang (ORCID: https://orcid.org/0000-0001-6833-8540)
- Peixiao Yin (ORCID: https://orcid.org/0009-0008-8521-0408)
- Yangdanyu Li (ORCID: https://orcid.org/0009-0002-1133-3065)
- Yating Fang
- Chuanying Xu
- Chenyang Guan
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fnins.2025.1667331
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Xuzhou Medical University