Detection of circulating hybrid cells and circulating tumor cells in cerebrospinal fluid for leptomeningeal metastasis diagnosis and therapeutic prediction
CSF-CTCs and CHCs represent promising biomarkers for LM diagnosis and therapeutic prediction with high sensitivity and specificity, complementing traditional MRI and cytology diagnostic approaches. These findings highlight their potential clinical utility and underscore the need for further studies to explore CHC formation mechanisms and their implications in LM pathogenesis and treatment strategies.
Authors
- Nianhua Cao (ORCID: https://orcid.org/0009-0008-6719-2824)
- Xiaodi Zhang
- Ruijuan Fan
- Min Zhang (ORCID: https://orcid.org/0000-0001-5108-1275)
- Zongbin Liu (ORCID: https://orcid.org/0000-0001-8117-0826)
- Kelei Zhao (ORCID: https://orcid.org/0000-0002-2515-065X)
- Zhiwei Chang (ORCID: https://orcid.org/0000-0001-5050-2939)
- Yan Li (ORCID: https://orcid.org/0000-0002-4658-2080)
- Yongxu Jia
- Guifang Zhang (ORCID: https://orcid.org/0000-0002-8203-1884)
- Ping Lu (ORCID: https://orcid.org/0009-0007-7771-3550)
- Yanting Liu (ORCID: https://orcid.org/0000-0001-5694-7197)
- Yinghua Ji
- Hongyan Hui
- Jiaxin Liang (ORCID: https://orcid.org/0000-0003-2129-3626)
- Jie Xue
- Guodong Zhang (ORCID: https://orcid.org/0000-0003-0114-2951)
Institutions
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Xinxiang Central Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fcell.2025.1716168
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Henan Provincial Science and Technology Research Project