Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study
Cancer and cancer treatment lead to significant epigenetic age acceleration, which can influence neuronal health and CRCI symptom onset. Furthermore, DNAm patterns corroborate BDNF as a potential biomarker for CRCI and suggest neurotrophin pathways play a meaningful role in CRCI etiology.
Authors
- Julia Trudeau (ORCID: https://orcid.org/0000-0002-3250-1876)
- M. Sayer (ORCID: https://orcid.org/0009-0001-5745-3110)
- Munjal M. Acharya (ORCID: https://orcid.org/0000-0002-7767-5642)
- Kord M. Kober (ORCID: https://orcid.org/0000-0001-9732-3321)
- Raymond J. Chan (ORCID: https://orcid.org/0000-0003-0248-7046)
- Alexandre Chan (ORCID: https://orcid.org/0000-0003-4391-4219)
- Ding Quan Ng (ORCID: https://orcid.org/0000-0002-0754-7901)
Institutions
- Flinders University (AU)
- University of California, San Francisco (US)
- University of California, Irvine (US)
- National Cancer Centre Singapore (SG)
- Irvine University (US)
Publication Details
- Journal
- Frontiers in Aging
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fragi.2025.1667638
- Citations
- 1
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Medical Research Council
- National Medical Research Council