Ischemia Reperfusion Injury Induced Systemic Inflammatory Response Following Interspecies Liver Transplantation
Although xenograft induced heightened inflammatory and adaptive responses, these were comparable to allotransplants. For successful exogenic organ transplantation without maintenance immunosuppression, future strategies must focus on mitigating reperfusion-induced systemic inflammation to improve graft tolerance and survival.
Authors
- Anala V. Shetty (ORCID: https://orcid.org/0000-0003-1185-3183)
- Walter C. Low (ORCID: https://orcid.org/0000-0001-8593-0175)
- Andrew Crane (ORCID: https://orcid.org/0000-0003-3452-2766)
- Magie Steinhoff
- Joseph Sushil Rao (ORCID: https://orcid.org/0000-0002-0197-6107)
- Anna Tran (ORCID: https://orcid.org/0000-0001-7165-2063)
- Parthasarathy Rangarajan (ORCID: https://orcid.org/0009-0003-5955-397X)
- Sabarinathan Ramachandran (ORCID: https://orcid.org/0000-0003-2239-8083)
- Clifford J. Steer (ORCID: https://orcid.org/0000-0003-0242-8433)
Institutions
- University of Minnesota (US)
Publication Details
- Journal
- Hepatic Medicine Evidence and Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/hmer.s533805
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases