Nirsevimab Effectiveness Against RSV‐Related Hospitalisations in Children Under 24 Months: A Test‐Negative Case–Control Study in Portugal, 2024–2025
We assessed Nirsevimab effectiveness (NE) against respiratory syncytial virus (RSV)-related hospitalisation in eligible children (< 2 years) using a test-negative case-control design within the VigiRSV network (weeks 43/2024 to 16/2025). Among 341 participants (median age: 2 months; 91.2% without known chronic condition), 137 (40.2%) tested RSV-positive. Adjusted NE against RSV-related hospitalisation was 78.5% (95%CI: 59.3-89.0). Sensitivity analyses confirmed the robustness of the results. These findings support Nirsevimab's effect in a predominantly healthy infant population and contribute to informing public health decisions for RSV immunisation.
Authors
- Paulo Lopes (ORCID: https://orcid.org/0000-0002-3128-1365)
- Madalena von Hafe (ORCID: https://orcid.org/0000-0003-4427-2262)
- Ana Loureiro (ORCID: https://orcid.org/0000-0003-0758-4662)
- Inês Carvalho
- Jorge Rodrigues (ORCID: https://orcid.org/0000-0002-1418-7860)
- Margarida Freitas
- Cristina Freitas (ORCID: https://orcid.org/0000-0002-0462-3366)
- Inês Azevedo (ORCID: https://orcid.org/0000-0002-0090-8612)
- Teresa Nunes (ORCID: https://orcid.org/0000-0002-0950-0955)
- Sara Ferreira (ORCID: https://orcid.org/0000-0001-7469-3186)
- Paulo Paixão (ORCID: https://orcid.org/0000-0002-4294-0872)
- Ana Paula Rodrigues (ORCID: https://orcid.org/0000-0003-2264-4723)
- Sofia Gomez (ORCID: https://orcid.org/0000-0002-0900-6519)
- João Farela Neves (ORCID: https://orcid.org/0000-0003-4740-6094)
- Camila Henriques (ORCID: https://orcid.org/0000-0002-3654-4929)
- José Antônio Barreto Alves (ORCID: https://orcid.org/0000-0002-8647-8050)
- Carolina Constant (ORCID: https://orcid.org/0000-0002-6596-1596)
- Teresa Bandeira (ORCID: https://orcid.org/0000-0002-6214-3117)
- Ausenda Machado (ORCID: https://orcid.org/0000-0002-1849-1499)
- Sara Soares (ORCID: https://orcid.org/0000-0002-7996-0519)
- Vânia Gaio (ORCID: https://orcid.org/0000-0001-7626-4991)
- Raquel Marques (ORCID: https://orcid.org/0000-0002-6701-3530)
- Raquel Guiomar (ORCID: https://orcid.org/0000-0002-4563-6315)
- Margarida Farinha
- Madalena Malato (ORCID: https://orcid.org/0009-0005-9341-648X)
- Rita Canas‐Marques (ORCID: https://orcid.org/0000-0002-7184-4230)
- Sofia Almeida (ORCID: https://orcid.org/0000-0001-7562-975X)
- Diana Amaral (ORCID: https://orcid.org/0009-0009-3210-3542)
- Diana Soares (ORCID: https://orcid.org/0000-0003-0589-0658)
- Rafaela Fernandes Gonçalves
- Miguel Lança (ORCID: https://orcid.org/0000-0003-0376-2572)
- Beatriz Sousa
- Regina Viseu
- Marta Rodrigues
- Teresa Graça
- Inês Piscalho
Institutions
- Hospital Center of Cova da Beira (PT)
- National School of Public Health (GR)
- Lusíada University of Lisbon (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Algarve Biomedical Center (PT)
- Hospital da Luz (PT)
- Centro Hospitalar de Vila Nova de Gaia (PT)
- National Institute of Health Dr. Ricardo Jorge (PT)
- Câmara Municipal de Almada (PT)
- Hospital de Santa Maria (PT)
- Hospital Dr. Nélio Mendonça (PT)
- University of Algarve (PT)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Influenza and Other Respiratory Viruses
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1111/irv.70186
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00