Metabolic Profiling of Sitravatinib in Rat and Human Liver Microsomes Using LC–MS/MS and LC–Orbitrap–HRMS
Key metabolic pathways included O-demethylation, amide formation, N-dealkylation, and oxidative deamination. This study establishes the first integrated LC-MS/MS and HRMS strategy for in vitro metabolic profiling of sitravatinib.
Authors
- Ying Zhu (ORCID: https://orcid.org/0000-0002-1946-8565)
- Gaobin Bao
- Wenxia Liu (ORCID: https://orcid.org/0000-0002-0784-018X)
- Shan Xu
- Linfei Li (ORCID: https://orcid.org/0009-0008-5086-3548)
Institutions
- Xuzhou Central Hospital (CN)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1002/rcm.70001
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00