Oral administration of recombinant Bacillus subtilis spores induces protective immunity against Echinococcus granulosus infection in dogs
This study demonstrates that B. subtilis spores serve as a safe and effective bacterial carrier to deliver E. granulosus antigens, supporting their potential in protecting dogs against E. granulosus infection. The heterogeneity in immune responses among vaccinated dogs should be addressed in future studies to secure consistent herd-level protection.
Authors
- Guoqing Shao (ORCID: https://orcid.org/0000-0002-0346-9248)
- Guangyou Yang (ORCID: https://orcid.org/0000-0003-3177-0908)
- X.-S. Zhu (ORCID: https://orcid.org/0009-0008-7477-3299)
- Ruiqi Hua
- Zhe Sun (ORCID: https://orcid.org/0000-0002-7967-8185)
- Luo Wang
- Zhiwei Lü (ORCID: https://orcid.org/0000-0003-1777-4611)
Institutions
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1186/s13071-025-07172-5
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00