Electroacupuncture modulates myocardial insulin signaling and inflammatory markers in a rat model of type 2 diabetes
EA ameliorated myocardial IR in a rat model of T2DM and positively impacted TNNT2 and BNP levels, as well as phosphorylation status and mRNA expression of several genes involved in the insulin signaling pathway. Our findings underscore the potential of EA to modulate multiple therapeutic targets in the treatment of myocardial IR. If these effects can be replicated clinically, EA may represent a promising non-pharmacological option for the management of cardiometabolic risks associated with diabetes.
Authors
- Linlin Nie (ORCID: https://orcid.org/0000-0002-7913-7450)
- Haihua Zhang (ORCID: https://orcid.org/0000-0003-1651-5167)
- Xiao-zhuan Chen
- Yang-yang Ye
- Lu Zhang (ORCID: https://orcid.org/0000-0002-1061-4781)
- Min Li (ORCID: https://orcid.org/0000-0002-7113-2700)
- Zhixing Li (ORCID: https://orcid.org/0000-0001-8495-4319)
- Jian Sun (ORCID: https://orcid.org/0000-0001-7189-8493)
- Jinxing Quan (ORCID: https://orcid.org/0000-0002-4517-3904)
- Xiaoxiao Liu (ORCID: https://orcid.org/0000-0001-9321-0784)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Acupuncture in Medicine
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1177/09645284251399239
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00