Conformational stability of hemocyanins regulates their lysosomal and proteasomal degradation, influencing their pro-inflammatory effects on mammalian antigen-presenting cells
These findings emphasize that hemocyanins, owing to their complex oligomeric structure and high stability, are slowly processed by APCs, thereby contributing to their immunogenicity. This property is particularly relevant when hemocyanins are used as carriers for vaccine antigens because their delayed kinetics can enhance the magnitude, quality, and persistence of responses.
Authors
- Byron Castillo
- Fabián Salazar (ORCID: https://orcid.org/0000-0001-5139-2292)
- Alejandra Alvarado (ORCID: https://orcid.org/0000-0002-4673-4996)
- Claudia d’Alençon
- Diego A. Díaz-Dinamarca (ORCID: https://orcid.org/0000-0001-5677-920X)
- Augusto Manubens (ORCID: https://orcid.org/0000-0002-7931-4314)
- Michelle L. Salazar (ORCID: https://orcid.org/0000-0001-5692-9730)
- Marı́a Inés Becker (ORCID: https://orcid.org/0000-0002-9711-2222)
- Juan Bustamante
Institutions
- Universidad del Desarrollo (CL)
- Emory University (US)
- Fundación Chile (CL)
- University of Exeter (GB)
- Exeter City Council (GB)
- University of Chile (CL)
- Medical Research Council (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1603070
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Chile
- Universidad Nacional de Cuyo
- Agencia Nacional de Investigación y Desarrollo