TREM-1 inhibitor specificity and timing of treatment initiation can impact its therapeutic efficacy in cancer and inflammatory disease

These findings for the first time demonstrate that both inhibitor specificity and timing of treatment initiation are crucial for therapeutic TREM-1 inhibition. This has significant implications for clinical strategies targeting TREM-1, particularly informing tailored treatment approaches for cancer and inflammatory diseases.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-12-01
DOI
https://doi.org/10.3389/fonc.2025.1689771
Primary Topic
Inflammation biomarkers and pathways
Type
article
Field-Weighted Citation Impact
0.00

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article

TREM-1 inhibitor specificity and timing of treatment initiation can impact its therapeutic efficacy in cancer and inflammatory disease

Alexander B. Sigalov
Frontiers in Oncology
Inflammation biomarkers and pathways
article

TREM-1 inhibitor specificity and timing of treatment initiation can impact its therapeutic efficacy in cancer and inflammatory disease

Alexander B. Sigalov
article en

Abstract

These findings for the first time demonstrate that both inhibitor specificity and timing of treatment initiation are crucial for therapeutic TREM-1 inhibition. This has significant implications for clinical strategies targeting TREM-1, particularly informing tailored treatment approaches for cancer and inflammatory diseases.

Frontiers in OncologyVol. 15
SignaBlok (United States) (US)
National Institutes of Health, National Heart, Lung, and Blood Institute, National Eye Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Openalex Percentile: Top 58%
Inflammation biomarkers and pathways
DOIOpen Access PDFOpenAlex
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TREM-1 inhibitor specificity and timing of treatment initiation can impact its therapeutic efficacy in cancer and inflammatory disease — Alexander B. Sigalov · Frontiers in Oncology (2025) | TGRS Research Map | TGRS