Antitumor efficacy of 5-aminolevulinic acid (5-ALA)-based radiodynamic therapy under single-dose X-ray irradiation in colon cancer

This study demonstrates for the first time that 5-ALA combined with single-dose X-ray irradiation exerts a strong antitumor effect on HT-29 xenografts. The observed effects may be mediated by induction of immunogenic cell death, modulation of the tumor microenvironment, and suppression of tumor cell survival pathways. These findings highlight single-dose 5-ALA-based RDT as a potential novel therapeutic strategy.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-12-01
DOI
https://doi.org/10.3389/fonc.2025.1722919
Citations
1
Primary Topic
Photodynamic Therapy Research Studies
Type
article
Field-Weighted Citation Impact
1.52

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article

Antitumor efficacy of 5-aminolevulinic acid (5-ALA)-based radiodynamic therapy under single-dose X-ray irradiation in colon cancer

Junko Takahashi, Xiupeng Wang, Shinsuke Nagasawa
1 citations
Frontiers in Oncology
Photodynamic Therapy Research Studies
1.52
article

Antitumor efficacy of 5-aminolevulinic acid (5-ALA)-based radiodynamic therapy under single-dose X-ray irradiation in colon cancer

Junko Takahashi, Xiupeng Wang, Shinsuke Nagasawa
article en
1 citations

Abstract

This study demonstrates for the first time that 5-ALA combined with single-dose X-ray irradiation exerts a strong antitumor effect on HT-29 xenografts. The observed effects may be mediated by induction of immunogenic cell death, modulation of the tumor microenvironment, and suppression of tumor cell survival pathways. These findings highlight single-dose 5-ALA-based RDT as a potential novel therapeutic strategy.

Frontiers in OncologyVol. 15
Waseda University (JP), The University of Kitakyushu (JP), Kyoto Prefectural University of Medicine (JP), National Institute of Advanced Industrial Science and Technology (JP)
Japan Society for the Promotion of Science
Openalex Percentile: Top 12%
Photodynamic Therapy Research Studies
1.52
DOIOpen Access PDFOpenAlex
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Antitumor efficacy of 5-aminolevulinic acid (5-ALA)-based radiodynamic therapy under single-dose X-ray irradiation in colon cancer — Junko Takahashi, Xiupeng Wang, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS