Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury
This study establishes a mechanistic link between elevated lipolysis and CNS inflammation following severe burns. Acipimox effectively modulates lipid profiles and reduces neuroinflammation, underscoring its potential for managing burn-induced neurological complications. Further studies are needed to validate these findings and explore clinical applications.
Authors
- William K. Russell (ORCID: https://orcid.org/0000-0003-1931-4555)
- Sean T. O’Leary (ORCID: https://orcid.org/0000-0003-2365-582X)
- Andrew J. Murton (ORCID: https://orcid.org/0000-0002-9474-9113)
- Steven E. Wolf (ORCID: https://orcid.org/0000-0003-2972-3440)
- Amina El Ayadi (ORCID: https://orcid.org/0000-0002-3657-0633)
- Anesh Prasai (ORCID: https://orcid.org/0000-0002-2598-9105)
- Rishi Deshpande
- Ariadna Robledo (ORCID: https://orcid.org/0000-0002-7981-6103)
- Ye Wang (ORCID: https://orcid.org/0000-0002-6729-7182)
- Christopher Thang (ORCID: https://orcid.org/0000-0003-2883-4974)
Institutions
- University of Miami (US)
- John Sealy Hospital (US)
- Shriners Hospitals for Children - Galveston (US)
- Massachusetts General Hospital (US)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1709256
- Citations
- 1
- Primary Topic
- Burn Injury Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.35