Increased risk of hyperthyroidism induced by immune checkpoint inhibitors in patients with existing or prior Graves’ disease: a nested prospective cohort study with propensity score matching
Patients with existing or prior Graves' disease have an increased risk of hyperthyroidism following ICI treatment, highlighting their need for careful differential diagnosis of thyrotoxicosis.
Authors
- Tetsushi Izuchi
- Mariko Sugiyama (ORCID: https://orcid.org/0000-0001-6289-1249)
- Koji Suzuki (ORCID: https://orcid.org/0000-0002-3235-9558)
- Shintaro Iwama (ORCID: https://orcid.org/0000-0002-3281-0337)
- Ryoichi Banno (ORCID: https://orcid.org/0000-0002-8546-1636)
- Hidetaka Suga (ORCID: https://orcid.org/0000-0003-1924-7639)
- Hiroshi Arima (ORCID: https://orcid.org/0000-0003-3746-1997)
- Takeshi Onoue (ORCID: https://orcid.org/0000-0002-8589-9937)
- Masahiko Ando (ORCID: https://orcid.org/0000-0003-2891-5424)
- Takayo Murase (ORCID: https://orcid.org/0000-0002-4515-9504)
- Tomoko Handa (ORCID: https://orcid.org/0000-0003-3729-9512)
- Tomoko Kobayashi (ORCID: https://orcid.org/0000-0002-4251-4865)
- Takashi Miyata (ORCID: https://orcid.org/0000-0002-1479-2251)
- Daisuke Hagiwara (ORCID: https://orcid.org/0000-0002-4353-231X)
Institutions
- Nagoya University Hospital (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fendo.2025.1701500
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00