Biphasic effect of nicotine on glutamatergic activity in male mouse brain
Nicotine has biphasic impacts on glutamatergic activity, enhancing excitatory activity at low doses but reducing both excitatory and inhibitory activity at higher doses. Most interestingly, acute nicotine increases neuronal excitability by shifting the excitation-to-inhibition balance in the prefrontal cortex, a critical component of the mesocortical circuitry.
Authors
- Ajay Sarawagi (ORCID: https://orcid.org/0000-0002-5417-946X)
- Anant Bahadur Patel (ORCID: https://orcid.org/0000-0002-9551-9395)
- Prajakta Pramod Biyani (ORCID: https://orcid.org/0009-0006-5912-5440)
Institutions
- Centre for Cellular and Molecular Biology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-30
- DOI
- https://doi.org/10.1111/bph.70242
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00