Role of visual and non-visual opsins in blue light–induced neurodegeneration in Drosophila melanogaster
Our findings demonstrate that the visual opsin Rh1 plays a predominant role in blue-light-induced DNA damage and neurodegeneration in the Drosophila central nervous system. This suggests that it is visual, rather than non-visual, opsins that mediate the neurotoxic effects of exposure to artificial light.
Authors
- Sandro Alves (ORCID: https://orcid.org/0000-0002-1396-7523)
- Juliano Morimoto (ORCID: https://orcid.org/0000-0003-3561-1920)
- Hulder Henrique Zaparoli (ORCID: https://orcid.org/0000-0001-6784-2083)
- Marina Piacenti‐Silva (ORCID: https://orcid.org/0000-0001-7096-3652)
- Carolina L. Zilli Vieira (ORCID: https://orcid.org/0000-0002-8763-3331)
- Marcela de Oliveira (ORCID: https://orcid.org/0000-0003-4144-7629)
Institutions
- Harvard University (US)
- University of Aberdeen (GB)
- King's College Hospital (GB)
- Universidade Federal do Paraná (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Frontiers in Public Health
- Published
- 2025-12-01
- DOI
- https://doi.org/10.3389/fpubh.2025.1644780
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo